儿童期受虐经历对大学生抑郁的影响：神经质人格和MAOA基因rs3027407多态性的作用

摘要/Abstract

摘要： 探讨儿童期受虐经历、神经质人格、MAOA基因rs3027407多态性与大学生抑郁之间的关系及内在作用机制，以311名大学生为研究对象使用流调中心抑郁量表、中文版儿童期虐待量表和艾森克人格问卷神经质分量表，并由专业护士对其抽取血液后进行DNA分型。结果表明：（1）儿童期受虐经历、神经质人格及大学生抑郁均呈显著正相关；（2）神经质人格在儿童期受虐经历与大学生抑郁的影响中起完全中介作用；（3）MAOA基因rs3027407多态性调节该中介模型后半段。

关键词: 儿童期受虐经历, 神经质人格, 大学生抑郁, MAOA基因

Abstract: To investigate the relationship and internal mechanism of childhood maltreatment, neurotic personality, MAOA gene rs3027407 polymorphism and depression among college students, a total of 311 college students were recruited in the current study. After given informed consents, they completed the Chinese Version of Childhood Trauma Questionnaire, Center for Epidemiological Studies Depression Scale (CES-D) and Eysenck Personality Questionnaire - the Neurotic Subscale. And DNA typing was performed after blood sampling by professional nurses. The results showed that: 1) childhood maltreatment, neurotic personality and college students’ depression were positively and significantly correlated with each other; 2) the effect of childhood maltreatment on depression in college students was almost fully mediated by neurotic personality; 3) MAOA gene rs3027407 polymorphism moderated the effect of neurotic personality on college students’ depression.

Key words: childhood maltreatment, neurotic personality, college students’ depression, MAOA gene

中图分类号:

B844

彭丽仪, 胡义秋, 曾子豪, 詹林. 儿童期受虐经历对大学生抑郁的影响：神经质人格和MAOA基因rs3027407多态性的作用[J]. 心理与行为研究, 2021, 19(2): 230-236.

PENG Liyi, HU Yiqiu, ZENG Zihao, ZHAN Lin. The Effect of Childhood Maltreatment on College Students’ Depression: The Role of Neurotic Personality and MAOA Gene rs3027407 Polymorphism[J]. Studies of Psychology and Behavior, 2021, 19(2): 230-236.

参考文献

曹丛, 王美萍, 纪林芹, 魏星, 曹衍淼, 张文新. (2016). MAOA基因rs6323多态性与母亲支持性教养对青少年抑郁的交互作用: 素质–压力假说与不同易感性假说的检验. 心理学报, 48(1), 22–35
陈祉妍, 杨小冬, 李新影. (2009). 流调中心抑郁量表在我国青少年中的试用. 中国临床心理学杂志, 17(4), 443–445, 448
程刚, 张大均. (2018). 家庭社会经济地位对大学新生抑郁情绪的影响: 有调节的中介模型. 心理与行为研究, 16(2), 247–252
龚耀先. (1984). 艾森克个性问卷在我国的修订. 心理科学通讯, (4), 11–19
凌宇. (2013). 神经质人格调节青少年应激与抑郁症状的追踪研究. 心理与行为研究, 11(3), 411–416
刘文, 刘方, 陈亮. (2018). 心理虐待对儿童认知情绪调节策略的影响: 人格特质的中介作用. 心理科学, 41(1), 64–70
宋锐, 刘爱书. (2013). 儿童心理虐待与抑郁: 自动思维的中介作用. 心理科学, 36(4), 855–859
宋煜青, 邓兆华, 郭琦, 刘肇瑞, 陈红光, 黄悦勤. (2018). 大学生抑郁症状的自然变化及影响因素的2年随访研究. 中国心理卫生杂志, 32(1), 64–71
唐慧, 丁伶灵, 宋秀丽, 黄志伟, 祁秦, 贺连平, 姚应水. (2013). 2002–2011年中国大学生抑郁情绪检出率的Meta分析. 吉林大学学报(医学版), 39(5), 965–969
王佳慧, 刘爱书. (2015). 大学生情绪调节自我效能感在虐待与抑郁间的中介作用. 中国心理卫生杂志, 29(4), 305–310
王美萍, 纪林芹, 张文新. (2015). MAOA基因rs6323多态性与同伴关系对男青少年早期抑郁的影响. 心理学报, 47(10), 1260–1268
温忠麟, 叶宝娟. (2014). 有调节的中介模型检验方法: 竞争还是替补. 心理学报, 46(5), 714–726
于增艳, 赵阿勐, 刘爱书. (2017). 儿童期受虐经历与抑郁的元分析. 心理学报, 49(1), 40–49, doi: 10.3724/SP.J.1041.2017.00040
赵幸福, 张亚林, 李龙飞, 周云飞. (2005). 儿童期虐待问卷中文版的信度及效度评估. 中国临床康复, 9(16), 209–211
周浩, 龙立荣. (2004). 共同方法偏差的统计检验与控制方法. 心理科学进展, 12(6), 942–950
周永红. (2016). 童年创伤经历与研究生主观幸福感的关系: 应对方式的中介作用. 中国临床心理学杂志, 24(3), 509–513
Belmaker, R. H., & Agam, G. (2008). Major depressive disorder. New England Journal of Medicine, 358(1), 55–68, doi: 10.1056/NEJMra073096.
Bronfenbrenner, U. (1979). The ecology of human development. Cambridge: Harvard University Press.
Chang, C. C., Chang, H. A., Fang, W. H., Chang, T. C., & Huang, S. Y. (2017). Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese. Journal of Affective Disorders, 207, 422–428, doi: 10.1016/j.jad.2016.08.055.
Cohen, J. (2013). Statistical power analysis for the behavioral sciences. Burlington: Elsevier Science.
Čugura, T., Boh, J., Zupanc, T., Pregelj, P., & Paska, A. V. (2018). Differences in SNP genotype distributions between complex and simple suicides. International Journal of Legal Medicine, 132(6), 1595–1601, doi: 10.1007/s00414-018-1820-x.
Dunn, E. C., Uddin, M., Subramanian, S. V., Smoller, J. W., Galea, S., & Koenen, K. C. (2011). Research review: Gene–environment interaction research in youth depression–A systematic review with recommendations for future research. Journal of Child Psychology and Psychiatry, 52(12), 1223–1238, doi: 10.1111/j.1469-7610.2011.02466.x.
Hayes, S. C. (1986). The case of the silent dog—Verbal reports and the analysis of rules: A review of Ericsson and Simon’s Protocol Analysis: Verbal Reports as Data. Journal of the Experimental Analysis of Behavior, 45(3), 351–363, doi: 10.1901/jeab.1986.45-351.
Hunt, T. K. A., Slack, K. S., & Berger, L. M. (2017). Adverse childhood experiences and behavioral problems in middle childhood. Child Abuse & Neglect, 67, 391–402, doi: 10.1016/j.chiabu.2016.11.005.
Karmakar, M., Elhai, J. D., Amialchuk, A. A., & Tietjen, G. E. (2018). Do personality traits mediate the relationship between childhood abuse and migraine? An exploration of the relationships in young adults using the add health dataset. Headache: The Journal of Head and Face Pain, 58(2), 243–259, doi: 10.1111/head.13206.
Kim, S. K., Park, H. J., Seok, H., Jeon, H. S., Chung, J. H., Kang, W. S., .. Shin, D. H. (2014). Association study between monoamine oxidase A (MAOA) gene polymorphisms and schizophrenia: Lack of association with schizophrenia and possible association with affective disturbances of schizophrenia. Molecular Biology Reports, 41(5), 3457–3464, doi: 10.1007/s11033-014-3207-5.
Laceulle, O. M., Ormel, J., Aggen, S. H., Neale, M. C., & Kendler, K. S. (2013). Genetic and environmental influences on the longitudinal structure of neuroticism: A trait-state approach. Psychological Science, 24(9), 1780–1790, doi: 10.1177/0956797613481356.
Nabavi, S. M., Daglia, M., Braidy, N., & Nabavi, S. F. (2017). Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review. Nutritional Neuroscience, 20(3), 180–194, doi: 10.1080/1028415X.2015.1103461.
Paulus, D. J., Vanwoerden, S., Norton, P. J., & Sharp, C. (2016). Emotion dysregulation, psychological inflexibility, and shame as explanatory factors between neuroticism and depression. Journal of Affective Disorders, 190, 376–385, doi: 10.1016/j.jad.2015.10.014.
Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1(3), 385–401.
Rice, F., Harold, G. T., & Thapar, A. (2002). Assessing the effects of age, sex and shared environment on the genetic aetiology of depression in childhood and adolescence. Journal of Child Psychology and Psychiatry, 43(8), 1039–1051, doi: 10.1111/1469-7610.00231.
Rogosch, F. A., & Cicchetti, D. (2004). Child maltreatment and emergent personality organization: Perspectives from the five-factor model. Journal of Abnormal Child Psychology, 32(2), 123–145, doi: 10.1023/B:JACP.0000019766.47625.40.
Sheikh, M. A., Abelsen, B., & Olsen, J. A. (2016). Differential recall bias, intermediate confounding, and mediation analysis in life course epidemiology: An analytic framework with empirical example. Frontiers in Psychology, 7, 1828, doi: 10.3389/fpsyg.2016.01828.
Smith, K. (2014). Mental health: A world of depression. Nature, 515(7526), 181, doi: 10.1038/515180a.
Spinhoven, P., Elzinga, B. M., van Hemert, A. M., de Rooij, M., & Penninx, B. W. (2016). Childhood maltreatment, maladaptive personality types and level and course of psychological distress: A six-year longitudinal study. Journal of Affective Disorders, 191, 100–108, doi: 10.1016/j.jad.2015.11.036.
Starr, L. R., Hammen, C., Conway, C. C., Raposa, E., & Brennan, P. A. (2014). Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study. Development and Psychopathology, 26(4 pt 2), 1241–1254, doi: 10.1017/S0954579414000996.
Thompson, R. J., Parker, K. J., Hallmayer, J. F., Waugh, C. E., & Gotlib, I. H. (2011). Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology, 36(1), 144–147, doi: 10.1016/j.psyneuen.2010.07.003.
Yu, Y. W. Y., Tsai, S. J., Hong, C. J., Chen, T. J., Chen, M. C., & Yang, C. W. (2005). Association study of a monoamine oxidase A gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology, 30(9), 1719–1723, doi: 10.1038/sj.npp.1300785.

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