The Functional Differentiation of the Lateral Prefrontal on the Behavior Control in the Context of Emotional and Non-emotional: A fNIRS Study

Abstract

Abstract: The right inferior frontal gyrus is generally considered a critical region for response inhibition. Recent studies, however, suggest that the role of this cortical area in response inhibition may be overstated and that the contributions of other regions of the prefrontal cortex(PFC)are often overlooked. To identify regions of the prefrontal cortex beyond the right inferior frontal gyrus which may serve to support response inhibition, the present study used fNIRS to record the change of oxygenated hemoglobin concentration of the lateral PFC, when our college students(right-handed)completed the go/no-go task under the non-emotional and the emotional contexts. As a result, under the non-emotional context, during response inhibition, the oxygenated hemoglobin concentration decreased in the bilateral dorsolateral prefrontal cortex(DLPFC)and the right orbito-frontal cortex(OFC); under the emotional context, the oxygenated hemoglobin concentration in the DLPFC and the bilateral ventrolateral prefrontal cortex(VLPFC)and OFC significantly deactivated. These results suggested that under the non-emotional and emotional context, bilateral DLPFC may work in behavioral inhibition in the form of neural activity inhibition. The VLPFC may not be the important area of behavioral inhibition, but the bilateral VLPFC is very important in the integration of emotional and behavioral control especially in the background of negative emotions. The VLPFC may be in the form of a greater degree of neural activity inhibition to finish the inhibition task.

Key words: non-emotional context, emotional context, behavior control, the lateral prefrontal cortex, functional near-infrared spectroscopy(fNIRS).

摘要： 采用功能性近红外脑成像技术（fNIRS），结合事件相关设计，在非情绪与情绪背景下，测量个体完成go/no-go任务时外侧前额叶皮层氧合血红蛋白浓度（HbO）的变化。结果发现：在非情绪背景下，行为抑制时双侧背外侧前额叶皮层和右眶额叶皮层负激活；在情绪背景下，行为抑制时双侧背外侧前额叶皮层和眶额皮层负激活，情绪与行为抑制的交互作用显著负激活双侧腹外侧前额叶皮层。结果表明：在非情绪与情绪背景下，双侧背外侧前额叶和右眶额叶皮层可能以神经抑制的活动形式参与行为抑制反应；腹外侧前额叶皮层可能不是行为抑制的重要脑区，但对情绪与行为抑制整合具有重要意义，特别是在负性情绪背景下，双侧腹外侧前额叶皮层可能以更大程度的神经抑制活动参与到情绪与行为抑制交互作用中来。

关键词: 非情绪背景, 情绪背景, 行为抑制, 外侧前额叶, fNIRS

CLC Number:

B842.6

Bai Xuejun, Liu Ying, Zhang Peng, Zhang Qihan. The Functional Differentiation of the Lateral Prefrontal on the Behavior Control in the Context of Emotional and Non-emotional: A fNIRS Study[J]. Studies of Psychology and Behavior, 2015, 13(5): 606-613.

白学军,刘颖,章鹏,张琪涵. 非情绪与情绪背景下行为抑制时外侧前额叶的功能分化：一项fNIRS研究*[J]. 心理与行为研究, 2015, 13(5): 606-613.

References

高艳霞.(2009). 儿童抑制加工的认知神经机制. 山东师范大学.
王琰, 蔡厚德.(2010). 反应抑制的心理加工模型与神经机制. 心理科学进展, 25(2), 220-229.
薛贵, 董奇, 张红川.(2004). 事件相关功能磁共振成像设计的基本原理及其优化. 中国神经科学杂志, 19(6), 420-425.
杨苏勇, 黄宇霞, 张慧君, 罗跃嘉.(2010). 情绪影响行为抑制的脑机制. 心理科学进展, 25(4), 605-615.
Aron, A. R., Robbins, T. W., & Poldrack, R. A.(2014). Inhibition and the right inferior frontal cortex: One decade on. Trends in cognitive sciences, 18(4), 177-185.
Asahi, S., Okamoto, Y., Okada, G., Yamawaki, S., & Yokota, N.(2004). Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study. European archives of psychiatry and clinical neuroscience, 254(4), 245-251.
Buckner, R. L., Andrews-Hanna, J. R., & Schacter, D. L.(2008). The brain's default network. Annals of the New York Academy of Sciences, 1124(1), 1-38.
Courtney, S. M.(2004). Attention and cognitive control as emergent properties of information representation in working memory. Cognitive, Affective, & Behavioral Neuroscience, 4(4), 501-516.
DeSouza, J. F., Menon, R. S., & Everling, S.(2003). Preparatory set associated with pro-saccades and anti-saccades in humans investigated with event-related FMRI. Journal of Neurophysiology, 89(2), 1016-1023.
Elliott, R., Rubinsztein, J. S., Sahakian, B. J., & Dolan, R. J.(2000). Selective attention to emotional stimuli in a verbal go/no-go task: An fMRI study. Neuroreport, 11(8), 1739-1744.
Ford, K. A., Goltz, H. C., Brown, M. R., & Everling, S.(2005). Neural processes associated with antisaccade task performance investigated with event-related FMRI. Journal of Neurophysiology, 94(1), 429-440.
Goldstein, M., Brendel, G., Tuescher, O., Pan, H., Epstein, J., Beutel, M., Silverman, M.(2007). Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: An emotional linguistic go/no-go fMRI study. Neuroimage, 36(3), 1026-1040.
Gray, J. R., Braver, T. S., & Raichle, M. E.(2002). Integration of emotion and cognition in the lateral prefrontal cortex. Proceedings of the National Academy of Sciences, 99(6), 4115-4120.
Hare, T. A., Tottenham, N., Davidson, M. C., Glover, G. H., & Casey, B.(2005). Contributions of amygdala and striatal activity in emotion regulation. Biological psychiatry, 57(6), 624-632.
Hare, T. A., Tottenham, N., Galvan, A., Voss, H. U., Glover, G. H., & Casey, B.(2008). Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task. Biological psychiatry, 63(10), 927-934.
Harper, J., Malone, S. M., & Bernat, E. M.(2014). Theta and delta band activity explain N2 and P3 ERP component activity in a go/no-go task. Clinical Neurophysiology, 125(1), 124-132.
Heilbronner, U., & Münte, T. F.(2013). Rapid event-related near-infrared spectroscopy detects age-related qualitative changes in the neural correlates of response inhibition. Neuroimage, 65, 408-415.
Herrmann, M. J., Plichta, M. M., Ehlis, A.-C., & Fallgatter, A. J.(2005). Optical topography during a Go–NoGo task assessed with multi-channel near-infrared spectroscopy. Behavioural brain research, 160(1), 135-140.
Hoshi, Y., Kobayashi, N., & Tamura, M.(2001). Interpretation of near-infrared spectroscopy signals: A study with a newly developed perfused rat brain model. Journal of Applied Physiology, 90(5), 1657-1662.
Leung, H.-C., & Cai, W.(2007). Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements. The Journal of Neuroscience, 27(37), 9893-9900.
Logan, G. D., & Cowan, W. B.(1984). On the ability to inhibit thought and action: A theory of an act of control. Psychological review, 91(3), 295-327.
Matsuda, G., & Hiraki, K.(2006). Sustained decrease in oxygenated hemoglobin during video games in the dorsal prefrontal cortex: a NIRS study of children. Neuroimage, 29(3), 706-711.
Matsuda, T., Matsuura, M., Ohkubo, T., Ohkubo, H., Matsushima, E., Inoue, K., …, Kojima, T.(2004). Functional MRI mapping of brain activation during visually guided saccades and antisaccades: Cortical and subcortical networks. Psychiatry Research: Neuroimaging, 131(2), 147-155.
Mazoyer, P., Wicker, B., & Fonlupt, P.(2002). A neural network elicited by parametric manipulation of the attention load. Neuroreport, 13(17), 2331-2334.
Nishimura, Y., Takizawa, R., Muroi, M., Marumo, K., Kinou, M., & Kasai, K.(2011). Prefrontal cortex activity during response inhibition associated with excitement symptoms in schizophrenia. Brain Research, 1370, 194-203.
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., Moore, G. J., Uhde, T. W., & Tancer, M. E.(2005). Neural substrates for voluntary suppression of negative affect: A functional magnetic resonance imaging study. Biological psychiatry, 57(3), 210-219.
Roberts, A., & Wallis, J.(2000). Inhibitory control and affective processing in the prefrontal cortex: Neuropsychological studies in the common marmoset. Cerebral Cortex, 10(3), 252-262.
Rodrigo, A. H., Di Domenico, S. I., Ayaz, H., Gulrajani, S., Lam, J., & Ruocco, A. C.(2014). Differentiating functions of the lateral and medial prefrontal cortex in motor response inhibition. Neuroimage, 85, 423-431.
Sakatani, K., Yamashita, D., Yamanaka, T., Oda, M., Yamashita, Y., Hoshino, T., Katayama, Y.(2006). Changes of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy. Life sciences, 78(23), 2734-2741.
Schaeffer, J. D., Yennu, A. S., Gandy, K. C., Tian, F., Liu, H., & Park, H.(2014). An fNIRS investigation of associative recognition in the prefrontal cortex with a rapid event-related design. Journal of neuroscience methods, 235, 308-315.
Schulz, K. P., Fan, J., Magidina, O., Marks, D. J., Hahn, B., & Halperin, J. M.(2007). Does the emotional go/no-go task really measure behavioral inhibition?: Convergence with measures on a non-emotional analog. Archives of Clinical Neuropsychology, 22(2), 151-160.
Swick, D., Ashley, V., & Turken, U.(2011). Are the neural correlates of stopping and not going identical? Quantitative meta-analysis of two response inhibition tasks. Neuroimage, 56(3), 1655-1665.
Xue, G., Aron, A. R., & Poldrack, R. A.(2008). Common neural substrates for inhibition of spoken and manual responses. Cerebral Cortex, 18(8), 1923-1932.

[1]	HU Zhe, ZHANG Jie, LI Cuihong, GUO Chunyan. The Effect of Valence and Arousal of Emotional Contexts on Source Memory [J]. Studies of Psychology and Behavior, 2020, 18(2): 185-192.
[2]	Wang Qin, Bai Xuejun, Li Shiyi. The Effect of Emotional Context and Expectation on Social Economic Decision-making [J]. Studies of Psychology and Behavior, 2015, 13(2): 191-197.