To clarify the basic situation and influencing factors of the prevalence of mental health problems among secondary school teachers in China, and to provide reliable data for strengthening the construction of social psychological service system and implementing teacher mental health maintenance and healthcare work, a meta-analysis was conducted on the retrieved research from 2000 to 2022. The results showed that: 1) the prevalence of mental health problems among secondary school teachers ranked from high to low, including sleep disorders (36.4%), compulsion (23.0%), depression (20.1%), anxiety (18.9%), paranoia (17.4%), hostility (16.7%), and somatization (16.6%); 2) school category, the year of publication, measurement tools, detection standards, and detection time were key factors that lead to varying levels of prevalence for mental health problems among secondary school teachers. In the future, more attention should be focused on the mental health problems of secondary school teachers. In specific, it is necessary to develop measurement tools that are suitable for the mental health status of secondary school teachers in China, as well as to unify screening standards; also, it is important to promote the normalization of screening, diagnosis, and intervention for secondary school teachers’ mental health problems.